EURURO Vol. 72 No. 5

665 860

Platinum Priority – Prostate Cancer
Editorial by Daniel E. Spratt on pp. 675–676 of this issue
A Prostate Cancer ‘‘Nimbosus’’: Genomic Instability and SChLAP1
Dysregulation Underpin Aggression of Intraductal and Cribriform
Subpathologies
Melvin L.K. Chua , Winnie Lo [2_TD$DIFF] Melania Pintilie Jure Murgic z, Emilie Lalonde
Vinayak Bhandari Osman Mahamud Anuradha Gopalan Charlotte F. Kweldam
Geert J.L.H. van Leenders Esther I. Verhoef Agnes Marije Hoogland Julie Livingstone
Alejandro Berlin Alan Dal Pra Alice Meng Junyan Zhang Miche`le Orain [5_TD$DIFF] [6_TD$DIFF]Vale´rie Picard
He´le`ne Hovington Alain Bergeron Louis Lacombe Yves Fradet Bernard Teˆtu
Victor E. Reuter Neil Fleshner Michael Fraser Paul C. Boutros
Theodorus H. van der Kwast [7_TD$DIFF] Robert G. Bristow [8_TD$DIFF]
a Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada; bInformatics and Biocomputing Program, Ontario Institute for Cancer
Research, Toronto, ON, Canada; c Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; dDepartment of Pathology, Memorial Sloan
Kettering Cancer Center, New York, NY, USA; e Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands; f Centre de [9_TD$DIFF]Recherche du CHU
de Que´bec-Universite´ Laval, Que´bec City, QC, Canada; g Division of Urology, University Health Network, University of Toronto, Toronto, ON, Canada;
h Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON, Canada; i Laboratory Medicine Program, University Health Network,
University of Toronto, Toronto, ON, Canada
ava ilable at
journal homepage:
Article info
Article history:
Accepted April 27, 2017
Associate Editor:
Stephen Boorjian
Keywords:
Intraductal carcinoma
Cribriform architecture
Abstract
Background: Intraductal carcinoma (IDC) and cribriform architecture (CA) represent
unfavorable subpathologies in localized prostate cancer. We recently showed that IDC
shares a clonal ancestry with the adjacent glandular adenocarcinoma.
Objective: We investigated for the co-occurrence of ‘‘aggression’’ factors, genomic
instability and hypoxia, and performed gene expression profiling of these tumors.
Design, setting, and participants: A total of 1325 men were treated for localized prostate
cancer from four academic institutions (University Health Network, CHU de Que´ bec-
Universite´ Laval, Memorial Sloan Kettering Cancer Center [MSKCC], and Erasmus
Medical Center). Pathological specimens were centrally reviewed. Gene copy number
and expression, and intraprostatic oxygenation were assessed.
y Current address: Division of Radiation Oncology, National Cancer Centre Singapore, Singapore.
z Current address: Department of Oncology and Nuclear Medicine, University Hospital Center Sisters
of Charity Zagreb School of Medicine, Zagreb, Croatia.
§ Current address: Department of Radiation Oncology, Bern University Hospital, Bern, Switzerland.
|| These authors shared co-senior authorship.
* Corresponding author.[10_TD$DIFF] Department of Pathology, Laboratory Medicine Program, Toronto General
Hospital, 200 Elizabeth St, Toronto, ON, M5G 2C4, Canada. Tel. +1 416 340 4597.
E-mail address: (T.H. van der Kwast).
** Corresponding author. Radiation Medicine Program, Princess Margaret Cancer Centre[11_TD$DIFF] and Depart-
ments of Medical Biophysics and Radiation Oncology, University of Toronto, 610 University [12_TD$DIFF]Ave,
Toronto, ON[13_TD$DIFF], M5G 2M9, Canada. Tel. +1 416 946 2936; Fax: +1 416 946 4442.
E-mail address: (R.G. Bristow).
0302-2838/# 2017 European Association of Urology. Published by Elsevier B.V. All rights reserved.