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Platinum Opinion

23

The Search for the Missing Heritability of Prostate Cancer

23

Brief Correspondence

26

Oncologic Outcomes for Patients with Residual Cancer at Cystectomy Following Neoadjuvant Chemotherapy: A Pathologic Stage-matched Analysis

26

Platinum Priorities

31

A Prostate Cancer “Nimbosus”: Genomic Instability and SChLAP1 Dysregulation Underpin Aggression of Intraductal and Cribriform Subpathologies

31

Prostate Cancer

41

Convergence of Genomic Instability and SChLAP1: Weathering the Storm of Intraductal Carcinoma of the Prostate

41

A Pragmatic Randomized Controlled Trial Examining the Impact of the Retzius- sparing Approach on Early Urinary Continence Recovery After Robot-assisted Radical Prostatectomy

43

Will Retzius-sparing Prostatectomy Be the Future of Prostate Cancer Surgery?

52

Adjuvant and Salvage Radiotherapy after Radical Prostatectomy in Prostate Cancer Patients

55

Post-prostatectomy Radiotherapy: Does “Salvage” Really Equal “Adjuvant”?

76

Cost of New Technologies in Prostate Cancer Treatment: Systematic Review of Costs and Cost Effectiveness of Robotic-assisted Laparoscopic Prostatectomy, Intensity-modulated Radiotherapy, and Proton Beam Therapy

78

Value of Prostate Cancer Care: New Information on New Therapies Suggest Less is More

102

Brachytherapy Boost Utilization and Survival in Unfavorable-risk Prostate Cancer

104

Optimal Radiotherapy for Unfavorable-risk Prostate Cancer

111

Kidney Cancer

113

Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma

113

Longer Telomere Length and Renal Cell Carcinoma

121

Voiding Dysfunction

123

Medical Treatment of Nocturia in Men with Lower Urinary Tract Symptoms: Systematic Review by the European Association of Urology Guidelines Panel for Male Lower Urinary Tract Symptoms

123

Anything New for Nocturia?

136

Stone Disease

138

What are the Benefits and Harms of Ureteroscopy Compared with Shock-wave Lithotripsy in the Treatment of Upper Ureteral Stones? A Systematic Review

138

Endoluminal versus Extracorporeal Endourology: Which is Better and at What Cost?

153

Education

155

Understanding and Improving Recruitment to Randomised Controlled Trials: Qualitative Research Approaches

155

Maximising Recruitment to Randomised Controlled Trials: The Role of Qualitative Research to Inform Recruitment Challenges

165

Guidelines

167

Prognostic Performance and Reproducibility of the 1973 and 2004/2016 World Health Organization Grading Classification Systems in Non–muscle-invasive Bladder Cancer: A European Association of Urology Non-muscle Invasive Bladder Cancer Guidelines Panel Systematic Review

167

Surgery in Motion

180

Midline Extraperitoneal Approach to Retroperitoneal Lymph Node Dissection in Testicular Cancer: Minimizing Surgical Morbidity

180

Original Articles

187

Prostate Cancer

187

Regular Aspirin Use and the Risk of Lethal Prostate Cancer in the Physicians’ Health Study

187

AR-V7 in Peripheral Whole Blood of Patients with Castration-resistant Prostate Cancer: Association with Treatment-specific Outcome Under Abiraterone and Enzalutamide

194

Preclinical Study using Malat1 Small Interfering RNA or Androgen Receptor Splicing Variant 7 Degradation Enhancer ASC-J9® to Suppress Enzalutamide-resistant Prostate Cancer Progression

201

Ability of a Genomic Classifier to Predict Metastasis and Prostate Cancer-specific Mortality after Radiation or Surgery based on Needle Biopsy Specimens

211

Words of Wisdom

219

Re: Association Between Direct-to-consumer Advertising and Testosterone Testing and Initiation in the United States, 2009–2013

219

Re: Incontinence Medication Response Relates to the Female Urinary Microbiota

220

Re: Multicenter Investigation of the Micro-organisms Involved in Penile Prosthesis Infection: An Analysis of the Efficacy of the AUA and EAU Guidelines for Penile Prosthesis Prophylaxis

220

Re: Critical Analysis of Early Recurrence After Laparoscopic Radical Cystectomy in a Large Cohort by the ESUT

221

Re: Robot-assisted Laparoscopic Prostatectomy Versus Open Radical Retropubic Prostatectomy: Early Outcomes from a Randomised Controlled Phase 3 Study

222

Re: Multi-institutional Assessment of Adverse Health Outcomes Among North American Testicular Cancer Survivors After Modern Cisplatin-based Chemotherapy

223

Research Letter

225

What is a “Diagnostic Test Reference Range” Good for?

225

Letters to the Editor published online

227

Re: Amar U. Kishan, Talha Shaikh, Pin-Chieh Wang, et al. Clinical Outcomes for Patients with Gleason Score 9–10 Prostate Adenocarcinoma Treated With Radiotherapy or Radical Prostatectomy: A Multi-institutional Comparative Analysis. Eur Urol 2017;71:766–73

227

Reply to Thomas Van den Broeck, R. Jeffrey Karnes, and Steven Joniau’s Letter to the Editor re: Amar U. Kishan, Talha Shaikh, Pin-Chieh Wang, et al. Clinical Outcomes for Patients with Gleason Score 9–10 Prostate Adenocarcinoma Treated With Radiotherapy or Radical Prostatectomy: A Multi-institutional Comparative Analysis. Eur Urol 2017;71:766–73

229

Re: Alessandro Morlacco, John C. Cheville, Laureano J. Rangel, Derek J. Gearman, R. Jeffrey Karnes. Adverse Disease Features in Gleason Score 3+4 “Favorable Intermediate-risk” Prostate Cancer: Implications for Active Surveillance. Eur Urol 2017;72:442–7

231

Re: Pascal Rischmann, Albert Gelet, Benjamin Riche, et al. Focal High Intensity Focused Ultrasound of Unilateral Localized Prostate cancer: A Prospective Multicentric Hemiablation Study of 111 Patients. Eur Urol 2017;71:267–73

232

Re: Maria Carmen Mir, Ithaar Derweesh, Francesco Porpiglia, Homayoun Zargar, Alexandre Mottrie, Riccardo Autorino. Partial Nephrectomy Versus Radical Nephrectomy for Clinical T1b and T2 Renal Tumors: A Systematic Review and Meta-analysis of Comparative Studies. Eur Urol 2017;71:606–17

233

Reply to Jae Heon Kim and Benjamin I. Chung’s Letter to the Editor re: Maria Carmen Mir, Ithaar Derweesh, Francesco Porpiglia, Homayoun Zargar, Alexandre Mottrie, Riccardo Autorino. Partial Nephrectomy Versus Radical Nephrectomy for Clinical T1b and T2 Renal Tumors: A Systematic Review and Meta-analysis of Comparative Studies. Eur Urol 2017;71:606–17

235

Re: Julien Dagenais, Matthew J. Maurice, Pascal Mouracade, Onder Kara, Ercan Malkoc, Jihad J. Kaouk. Excisional Precision Matters: Understanding the Influence of Excisional Volume Loss on Renal Function After Partial Nephrectomy. Eur Urol 2017;72:168–70

237

Reply to Jae Heon Kim and Benjamin I. Chung’s Letter to the Editor re: Julien Dagenais, Matthew J. Maurice, Pascal Mouracade, Onder Kara, Ercan Malkoc, Jihad J. Kaouk. Excisional Precision Matters: Understanding the Influence of Excisional Volume Loss on Renal Function After Partial Nephrectomy. Eur Urol 2017;72:168–70

239

Re: Thomas Powles, Robert A. Huddart, Tony Elliott, et al. Phase III, Double-blind, Randomized Trial that Compared Maintenance Lapatinib versus Placebo after First-line Chemotherapy in Patients with Human Epidermal Growth Factor Receptor 1/2-positive Metastatic Bladder Cancer. J Clin Oncol 2017;35:48–55 Knowing HER2 Status is Not Enough: A Molecular Subtype Approach to Bladder Cancer is Also Needed

241

Reply to Pontus Eriksson, Gottfrid Sjödahl, and Fredrik Liedberg’s Letter to the Editor re: Thomas Powles, Robert A. Huddart, Tony Elliott, et al. Phase III, Double-blind, Randomized Trial that Compared Maintenance Lapatinib versus Placebo after First-line Chemotherapy in Patients with Human Epidermal Growth Factor Receptor 1/2-positive Metastatic Bladder Cancer. J Clin Oncol 2017;35:48–55. Knowing HER2 Status is Not Enough: A Molecular Subtype Approach to Bladder Cancer is Also Needed

243

Re: Umberto Leone Roberti Maggiore, Simone Ferrero, Massimo Candiani, et al. Bladder Endometriosis: A Systematic Review of Pathogenesis, Diagnosis, Treatment, Impact on Fertility, and Risk of Malignant Transformation. Eur Urol 2017;71:790–807

245

Reply to Rodolfo Montironi, Silvia Gasparrini, Antonio Lopez-Beltran, et al’s Letter to the Editor re: Umberto Leone Roberti Maggiore, Simone Ferrero, Massimo Candiani, et al. Bladder Endometriosis: A Systematic Review of Pathogenesis, Diagnosis, Treatment, Impact on Fertility, and Risk of Malignant Transformation. Eur Urol 2017;71:790–807. Benign Müllerian Lesions in the Urinary Bladder: Endometriosis, Endocervicosis, Endosalpingiosis, and Müllerianosis

248

Congress Calendar

249

Addendum

253

Addendum to “Subgroups of Castration-resistant Prostate Cancer Bone Metastases Defined Through an Inverse Relationship Between Androgen Receptor Activity and Immune Response” [Eur Urol 2017;71:776–87]

253

Corrigendum

254

Corrigendum re: “Percutaneous Nephrolithotomy: Update, Trends, and Future Directions for Simultaneous Supine Percutaneous Nephrolithotomy and Retrograde Ureterolithotripsy in the Galdakao-modified Supine Valdivia Position for Large Proximal Ureteral Calculi” [Eur Urol 2017;71:837–8]

254