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Table 2 – Summary of the included studies

Study

Research setting

Qualitative methods

Bill-Axelson et al (2009)

[23]

Main study comparing radical prostatectomy with active monitoring

for prostate cancer in Sweden

Interviews with patients (

n

= 9) and clinicians (

n

= 5)

Blazeby et al (2009)

[24]

Feasibility study comparing chemoradiation versus chemotherapy

and surgery for oesophageal cancer in the UK

Interviews with patients (

n

= 14)

RCT consultations recorded (

n

= 26)

Donovan et al (2009)

[25]

Feasibility/main study comparing prostatectomy, radiotherapy, and

active monitoring for prostate cancer in UK

Interviews with recruiters and patients

RCT consultations recorded

Donovan et al (2014)

[27]

Six UK RCTs in a range of clinical contexts, with different types of RCT

interventions, with a range of primary recruiters, and at different

stages of the implementation of the RCT

Interviews with clinicians and nurses (

n

= 72)

Donovan et al (2014)

[28]

Six UK RCTs in a range of clinical contexts, with different types of RCT

interventions, with a range of primary recruiters, and at different

stages of the implementation of the RCT

Interviews with clinicians (

n

= 32)

French et al (2016)

[29]

Specialist nurses from a variety of research studies (including RCTs) in

general adult acute care or community settings in the UK

Interviews with specialist nurses (

n

= 12)

Hales et al (2001)

[30]

RCT for an HIV drug in Australia

Interviews with clinicians (

n

= 10)

Griffin et al (2016)

[31]

Feasibility study comparing surgery and nonoperative care for hip

impingement in the UK

Interviews with TMG (

n

= 10) and clinicians (

n

= 21)

RCT consultations recorded (

n

= 87)

Hamilton et al (2013)

[32]

Feasibility study comparing surgery or radiotherapy for laryngeal

cancer in the UK

Interviews with clinicians and research nurses

RCT consultations recorded

Horwood et al (2016)

[33]

Main study comparing intraoperative local anaesthetic wound

infiltration or usual care for joint pain in the UK

Interviews with patients (

n

= 24) and clinicians/nurses

(

n

= 15)

Lamb et al (2016)

[34]

Community nurses involved in wound care trials in the UK

Interviews with research nurses (

n

= 8)

Langley et al (2000)

[35]

Clinicians recruiting to cancer trials in the UK

Interviews with clinicians (

n

= 20)

Lawton et al (2015)

[36]

Type 1 diabetes main RCT comparing multiple daily injections or

pump therapy in the UK

Interviews with clinicians and nurses (

n

= 18)

Lawton et al (2016)

[37]

Peripartum pilot RCT comparing drug with placebo in the UK

Interviews with clinicians/nurses (

n

= 27) and patients

(

n

= 22)

Mann et al (2014)

[38]

Pilot study comparing intraoperative local anaesthetic wound

infiltration or usual care for joint pain in the UK

RCT consultations recorded (

n

= 53)

Mason et al (2007)

[39]

Main study comparing types of antidepressants for depression RCT in

the UK

Interviews with recruiting GPs (

n

= 41)

Mills et al (2014)

[40]

Feasibility/main study comparing prostatectomy, radiotherapy, and

active monitoring for prostate cancer in the UK and two anonymised

RCTs

RCT consultations recorded (

n

= 103)

Mills et al (2011)

[41]

Feasibility/main study comparing prostatectomy, radiotherapy, and

active monitoring for prostate cancer in the UK

RCT consultations recorded (

n

= 93)

McIntosh et al (2005)

[42]

Smoking cessation trial in the USA

Focus groups with clinicians (

n

= 30)

Newington et al (2014)

[43]

Clinicians and nurses involved in research (including RCTs) in the UK Interviews with clinicians and nurses (

n

= 11)

Paramasivan et al (2011)

[44]

Feasibility study comparing surgery with radiotherapy for bladder

cancer in the UK

Interviews with clinicians/nurses (

n

= 9) and TMG (

n

= 2)

RCT consultations recorded (

n

= 4)

Paramasivan et al (2015)

[45]

Two anonymised UK RCTs differed in clinical contexts and complexity

of the recruitment process

Interviews with clinicians/nurses (

n

= 20) and patients

(

n

= 23)

RCT consultations recorded (n = 35)

Patterson et al (2010)

[46]

Main RCT comparing art therapy with usual care for schizophrenia in

the UK

Interviews and focus groups with clinicians (

n

= 17)

Potter et al (2009)

[47]

Main RCT comparing telephone support with usual care for type

2 diabetes in the UK

Interviews with nurses (

n

= 10)

Potter et al (2014)

[48]

Hypothetical feasibility RCT in breast reconstruction after

mastectomy for breast cancer in the UK

Interviews with clinicians (

n

= 31)

Rooshenas et al (2016)

[49]

Six UK RCTs in a range of clinical contexts, with different types of RCT

interventions, with a range of primary recruiters, and at different

stages of the implementation of the RCT

Interviews with clinicians (

n

= 23)

RCT consultations recorded (

n

= 105)

de Salis et al (2008)

[50]

Five UK RCTs in a range of clinical contexts, with different types of

RCT interventions, with a range of primary recruiters, and at different

stages of the implementation of the RCT

Interviews with clinicians and nurses

RCT consultations recorded

Spilsbury et al (2008)

[51]

Main RCT comparing alternating pressure mattress overlays and

replacements

Focus group with nurses (

n

= 9)

Stein et al (2016)

[52]

Feasibility RCT comparing test direct chemotherapy versus usual care

in the UK

Interviews with clinicians and nurses (

n

= 14)

RCT consultations recorded (

n

= 36)

Stuart et al (2015)

[53]

Main RCT comparing home-based support with usual care for

pregnant women in the UK

Interviews with community midwives (

n

= 13)

Strong et al (2016)

[54]

Feasibility study comparing chemoradiation versus chemotherapy

and surgery for oesophageal cancer in the UK

Interviews with clinicians (

n

= 21)

Tomlin et al (2014)

[55]

Five UK RCTs in a range of clinical contexts, with different types of

RCT interventions, with a range of primary recruiters, and at different

stages of the implementation of the RCT

Interviews and focus groups with nurses (

n

= 43)

RCT consultations recorded (

n

= 23)

Wade et al (2009)

[13]

Feasibility/main study comparing prostatectomy, radiotherapy, and

active monitoring for prostate cancer in the UK

RCT consultations recorded (

n

= 23)

Zeibland et al (2007)

[56]

Main study comparing spinal rehabilitation with surgery for

treatment of chronic back pain in the UK

Interviews with clinicians (

n

= 11)

GP = general practitioner; RCT = randomised controlled trial; TMG = trial management group.

E U R O P E A N U R O L O G Y 7 2 ( 2 0 1 7 ) 7 8 9 – 7 9 8

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