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If clinicians use cutoff values to diagnose a disease, why
is reporting of the test reference range necessary? In each
region, the costs associated with false-negative and false-
positive results should be compared. In accordance with the
prevalence of the disease of interest in the region, each
laboratory should then present the most appropriate cutoff
value for diagnosis of the disease along with the test result
requested.
Conflicts of interest:
The authors have nothing to disclose.
References
[1]
Ozarda Y. Reference intervals: current status, recent developments and future considerations. Biochem Med (Zagreb) 2016;26: 5–16.
[2]
Habibzadeh F, Habibzadeh P, Yadollahie M. On determining the most appropriate test cut-off value: the case of tests with continu- ous results. Biochem Med (Zagreb) 2016;26:297–307.[3]
Sox HC, Higgins MC, Owens DK. Medical decision making. ed. 2 Oxford, UK: Wiley-Blackwell; 2013.[4]
Habibzadeh F, Habibzadeh P, Yadollahie M. Criterion used for determination of test cut-off value. Diabetes Res Clin Pract 2017; 128:138–9.[5]
Punglia RS, D’Amico AV, Catalona WJ, Roehl KA, Kuntz KM. Impact of age, benign prostatic hyperplasia, and cancer on prostate-specific antigen level. Cancer 2006;106:1507–13.
a
Student Research Committee, Shiraz University of Medical Sciences,
Shiraz, Iran
b
R&D Headquarters, Petroleum Industry Health Organization, Shiraz, Iran
*Corresponding author. Shiraz University of Medical Sciences,
P.O. Box 71955-575, Shiraz 71955, Iran. Tel./Fax: +98 71 32252258.
E-mail address:
farrokh.habibzadeh@theijoem.com(F. Habibzadeh).
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