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Author contributions:

Kemal Sarica had full access to all the data in the

study and takes responsibility for the integrity of the data and the

accuracy of the data analysis.

Study concept and design:

Drake, Grivas, Maclennan, Debastani,

Skolarikos, Tuerk, Knoll, Straub, Seitz, Petrik, Lam, Sarica.

Acquisition of data:

Yuan, Drake, Grivas.

Analysis and interpretation of data:

Maclennan, Drake, Grivas, Debastani,

Sarica.

Drafting of the manuscript:

Drake, Grivas, Maclennan, Debastani, Sarica.

Critical revision of the manuscript for important intellectual content:

Drake,

Grivas, Maclennan, Debastani, Skolarikos, Tuerk, Sarica.

Statistical analysis:

None.

Obtaining funding:

None.

Administrative, technical, or material support:

None.

Supervision:

Debastani, Tuerk, Sarica.

Other:

None.

Financial disclosures:

Kemal Sarica certifies that all conflicts of interest,

including specific financial interests and relationships and affiliations

relevantto the subjectmatter ormaterials discussed in themanuscript(eg,

employment/affiliation, grants or funding, consultancies, honoraria, stock

ownership or options, expert testimony, royalties, or patents filed,

received, or pending), are the following: Knoll: company consultant

(Schoelly, Boston Scientific, Olympus, Storz Medical), company speaker

honorarium (Karl Storz, Richard Wolf, Olympus, Boston Scientific, Ibsen),

trial participation Cook, Coloplast; Straub: company consultant (Richard

Wolf Endoskope, Knittlingen, Germany), Sanochemia Pharmazeutika AG,

Vienna (Statistik Austria, #674), Porge`s Coloplast. Seitz: company

consultant (Astellas), company speaker honorarium (ROWA Wagner

GmbH & Co KG); Petrik: company speaker honorarium (Olympus, Cook),

fellowship, travel grants (Astellas Olympus); Lam: company consultant

(Pfizer, GSK, Astellas, Ipsen), company speaker honorarium (Pfizer, GSK,

Astellas, Ipsen).

Funding/Support and role of the sponsor:

None.

Appendix A. Supplementary data

Supplementary data associated with this article can be

found, in the online version, at

http://dx.doi.org/10.1016/j. eururo.2016.04.035 .

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