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[8]

McConkey DJ, Choi W, Shen Y, et al. A prognostic gene expression signature in the molecular classification of chemotherapy-naive urothelial cancer is predictive of clinical outcomes from neoadju- vant chemotherapy: a phase 2 trial of dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin with bevacizumab in urothelial cancer. Eur Urol 2016;69:855–62.

[9]

Seiler R, Ashab HA, Erho N, et al. Impact of molecular subtypes in muscle-invasive bladder cancer on predicting response and surviv- al after neoadjuvant chemotherapy. Eur Urol 2017;72:544–54.

[10]

Bellmunt J, de Wit R, Vaughn DJ, et al. Pembrolizumab as second- line therapy for advanced urothelial carcinoma. N Engl J Med 2017;376:1015–26.

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Powles T, Smith K, Stenzl A, Bedke J. Immune checkpoint inhibition in metastatic urothelial cancer. Eur Urol 2017;72:477–81

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[12]

Rosenberg JE, Hoffman-Censits J, Powles T, et al. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Lancet 2016;387:1909–20.

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Balar AV, Galsky MD, Rosenberg JE, et al. Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial. Lancet 2017;389:67–76

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Thomas Powles*

Alfonso

[1_TD$DIFF]

Go´mez de

[6_TD$DIFF]

Lian˜o

Charlotte Ackerman

Department of Oncology, Barts Cancer Institute, London, UK

*Corresponding author. Barts Cancer Institute, Oncology, Charterhouse

Square, London EC1M 6BQ, UK. Tel. +44 7932048109.

E-mail address:

thomas.powles@bartshealth.nhs.uk

(T. Powles).

May 15, 2017

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